Indications:

Non – obstructive constipation

purgative (in high doses)

PHARMACOLOGIC ACTIONS

The ß-linked glucosides ( sennosides ) are not absorbed in the upper gut ; they are converted by the bacteria of the large intestine into rhein anthrone(1,8 dihydroxyanthracene derivative which is the active metabolite) and by stimulation of peristaltic contractions resulting in accelerated colonic transit , thus reducing fluid absorption .

ACTIVE INGREDIENTS

Each 5ml contains: 225mg Senna liquid extract (equivalent to 7.5mg Sennoside B)

ADMINISTRATION AND DOSAGE

Shake well befor using .

– Children 2 to 6 years of age: 2.5 – 5ml (0.5 – 1 teaspoon) daily .

– Children 6 to 12 years of age: 5-10ml (1 – 2 teaspoons) daily .

– Adults and children over 12 years of age : 10 – 20ml (2 – 4 teaspoons) daily.

INTERACTIONS

There is an interaction with cardiac glycosides and Anti-arrhythmic agents.

ADVERSE REACTIONS

 It may cause yellow – brown or reddish discoloration of urine which is not clinically significant .

Senna may cause cramps and abdominal pain. spearmint oil is used for its antispasmodic and carminative effect in this medicine.

CONTRAINDICATIONS & PRECAUTIONS

As for all laxatives , it should not be given in cases of :

abdominal Pain with unknown origin , intestinal obstruction , acute inflammatory intestinal diseases or appendicitis .

PREGNANCY AND LACTATION

Avoid during pregnancy and lactation .

TIPS

Use for more than 2 weeks requires your prescribe or healthcare professional advice .

The medicine takes place after a latency period of 8-12 hours.

In daily use , the cause of the constipation should be investigated .

Administer before bedtime with one or two glasses of water.

STORAGE

Store below 30˚C and protect from light and moisture.

IRC

1228170034

REFERENCES

1) PDR for herbal medicines (2008), 726 – 727 , 758-759 .

2) Remington’s pharmaceutical sciences (1990), 785-6.

3) Martindale, the complete drug reference (2002), 1248-1249.

4) European Scientific cooperative on phytotherapy (E/S/C/O/P) ,(2003), 456-458 .

5)Zargari A.: Medicinal Plants, 1991, Vol. 2, 97 – 107.

6)British herbal Pharmacopoeia , (1983)  ,49-52 .