Digestive and biliary dysfunctions
Pain and inflammation of joints
Curcuma longa (Turmeric) is a medicinal plant with hepatoprotective, antioxidant and anti-inflammatory effects. Commission E approved this herb for dyspepsia (fullness and flatulence) and loss of appetite. Curcumin(the active ingredient of turmeric is responsible for yellow color of this powder)has free radical scavenging activities.
Curcumin provides an antioxidant and anti-inflammatory effect by inhibiting the binding of transcription factor AP-1 to DNA and activation of NF – Kappa B.
Curcumin inhibits epidermal arachidonic acid metabolism by means of lipoxygenase and cyclooxygenase pathways and reduces the inflammatory effects of arachidonic acid and tetradeconylphorbol-acetate. Turmeric has anti hepatotoxic, antihyperlipidemic, antithrombotic and anti-inflammatory effects.
A research shows that a daily intake of turmeric equivalent to 20mg of the antioxidant Curcumin for 60 days, decreases the high levels of peroxidation of both the HDL and the LDL, so Curcumin because of its antioxidant activity and lack of toxicity, might be a useful complement to standard hypo-lipidemic drugs in the prevention and treatment of atherosclerosis. Another study indicates that dietary turmeric is an effective anti-mutagen and it may be useful in chemoprevention.
Each tablet contains 450 mg Curcuma longa rhizome powder and 50mg Curcuma longa ext. standardized on 47.5 mg Curcumin.
ADMINISTRATION AND DOSAGE
Take 1 tablet daily with meal.
Avoid concomitant use of Curcuma tablet and anticoagulants and antiplatelet agents such as warfarin, aspirin, clopidogrel, heparin and low molecular weight heparins because it increases the risk of bleeding.
There is no adverse reaction in recommended dose. Nausea and vomiting can be occured in rare cases.
CONTRAINDICATIONS & PRECAUTIONS
Not recommended for people who have cholelithiasis and bile duct obstruction.
PREGNANCY AND LACTATION
This medicine is contra-indicated during pregnancy because of bleeding risk.
There is no documents about using during lactation.
Curcuma tablet must be stopped 2 weeks before operations.
Store below 30˚C and protect from light and moisture.
1-PDR for Herbal Medicines, Fourth Edition, (2007), 864-67.
2-Martindale, The complete Drug Reference, 38th Edition, (2014), Vol.2, 2218.
3-Iranian Herbal Pharmacopoeia , Vol.1, (1381);71.
4-ESCOP Monographs, the Scientific foundation for Herbal Medicinal products, second Edition,(2003), 107-17.
7-Turmeric the genus Curcuma Edited by P.N. Ravindran etal. P.443
8-A.Pamirez Bosca et al. Effects of the antioxidant turmeric on lipoprotein peroxides. Age(Omaha).Jul 1997; 20(3): 165-68.
9- Polasa K et al. Effect of turmeric on urinary mutagens in smokers. Mutagenesis. 1992 Mar; 7(2): 107-9.