Anti-inflammatory and sedative for pains resulting from peptic and deudenum ulcers
Enhancement of mucous resistance
Peptic and deudenum ulcers
Recent analyses have shown that the extracts of the abovementioned herbs contain components affecting gastritis and ulcers of stomach and deudenum; The most crucial ones being flavonoids, saponosides, and its mucilage compounds. Mechanism of action of Gastrodin is a series of mechanism related to its effective matters. Anti-ulcer effect of Glycyrrhiza glabra might be associated with stoppage of action between mucosal receptors and release of acetyl- choline of vagus nerves. In addition, it reinforces the mucous barrier against impact of gastric acid via influencing the chemical composition of stomach mucus. Mechanism of action of flavonoids in Glycyrrhiza glabra and calendula is also expressed based on anti-inflammatory effects of flavonoids that can prevent from release of histamines, and additionally, leave other impacts on them such as stabilization of lysosome membrane and influence on capillary permeability and strength. Mucilage of althaea off. also has protective effects on digestive system mucus.
Each Gastrodin tablet contains 400 mg of glycyrrhiza glabra root extract (whose glycyrrhizin content is reduced as far as possible) and extract of calendula off. flowers as well as althaea off root powder.
ADMINISTRATION AND DOSAGE
Observing the diet, one or two tablets before every meal for 4 to 6 weeks.
Gastrodin tablet can be prescribed solely or with anti-acid medications.
Gastrodin has interaction with medicines which can lower potassium such as Thiazide duretics and laxatives that contain senna.
Intake of total root and extract of licorice in long term, would result in elevated blood pressure and occurrence of mineralocorticoid symptoms due to presence of high glycyrrhizin . For the same reason, to minimize this side effect, Gastrodin tablet is made of Glycyrrhiza glabra extract with the lowest amount of glycyrrhizin.
CONTRAINDICATIONS & PRECAUTIONS
The medicine shall not be used in cases of acute renal failures, chronic hepatitis, biliary duct obstruction, liver cirrhosis , and hypokalemia.
In patients suffering from hypertension, Gastrodin shall be used with doctor’s advice and control of blood pressure.
PREGNANCY AND LACTATION
It is contraindicated.
The instances of analogous drugs already used in Iran are: Ulcedal, Rabro, Vigastrin, and Caved-s.
Store below 30°C and protect from moisture and light.
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21) British pharmacopoeia 2011, Appendix XVIB, XIM.
22) Iranian herbal pharmacopoeia, 1381, 520-527.