C-Lax Syrup

Pharmacological and Clinical Notes of C-Lax Syrup

Oral Senna, when used appropriately and for short-term, is an FDA-approved over-the-counter medication for adults and children over 2 years of age. The active constituents of Senna, without being absorbed in the small intestine, are converted by colonic bacteria into the active metabolite (1,8-dihydroxyanthracene derivatives), which increase intestinal peristalsis and thereby accelerate the transit of bowel contents.
In a clinical study conducted under the supervision of Golestan University of Medical Sciences, the efficacy of C-Lax syrup was compared with polyethylene glycol for bowel preparation prior to colonoscopy. It was demonstrated that consumption of three bottles of C-Lax syrup, divided into two doses 12 hours apart (1.5 bottles every 12 hours), 24 hours before colonoscopy, has a cleansing effect comparable to the intake of 20 glasses of 250 mL polyethylene glycol (one glass every 15 minutes over 24 hours).

Avipect Clinical Data (pdf)

Avipect Clinical Data (image)

Each bottle of C-Lax syrup contains:

Active Ingredients:

Active Ingredients	Amount
Senna alexandrina leaf liquid Ext.	50 mg/1ml, 250mg/5ml
(Standardized to 7.5 mg hydroxyanthracene glycosides as sennoside B/5 ml, 90mg/bottle)

No Alcohol - No Artificial Color
with natural flavor of spearmint

Other Ingredients:

Sucrose, Glycerin, Natural Spearmint oil, Nipagin, Nipasol, Purified water.

Dosage Instructions

Shake the bottle well before use

As a laxative:
Children 2 to 6 years: 2.5 to 5 mL daily
Children 6 to 12 years: 5 to 10 mL daily
Adults and children 12 years and older: 10 to 20 mL daily, if required, maximum twice daily.
For bowel evacuation: In adults and children 12 years and older, 1 to 2 bottles depending on body weight, to be taken between 2 and 4 PM the day before radiographic examinations and colonoscopy, or according to clinical study instructions, 1.5 bottles every 12 hours, 24 hours before the examinations.

please wash the measuring cup after use.

Precautions and contraindications:

- May cause discoloration of urine to red or yellowish-brown, which is not clinically significant.
- Since products containing Senna may cause abdominal pain and spasms in sensitive individuals, C-Lax syrup formulation includes natural and pleasant-tasting spearmint essential oil, which has anti-flatulence and antispasmodic effects.
- Like other laxatives, contraindicated in cases of abdominal pain of unknown origin, intestinal obstruction, acute inflammatory bowel diseases, and appendicitis.
- Due to the presence of sucrose, C-Lax syrup should be used in diabetic patients only under medical supervision.
- If daily use of laxatives is required, the cause of constipation should be investigated, as prolonged use of laxatives generally leads to electrolyte imbalances (especially potassium) and related adverse effects.
- Continuous use of Senna-containing products for more than two weeks is not recommended, as long-term use reduces the colon’s response to Sennosides, resulting in increased effective dose and associated side effects.
- Preferably, the medication should be taken before bedtime with 1 to 2 glasses of water.
- It takes 8 to 12 hours for the active constituents to reach the colon, be converted into active compounds, and exert laxative effects.
- This syrup is very easy to use in young children.
- In adults with swallowing difficulties, use of the syrup is recommended.
- In adults with swallowing difficulties, use of the syrup is recommended.
- Use of C-Lax syrup is associated with less abdominal cramping and pain compared to similar products.
- During pregnancy and lactation, appropriate short-term use under medical supervision can be considered safe.
- Use during breastfeeding does not affect the infant’s bowel movements.

Pregnancy & Lactation

Do not use during pregnancy.

interactions

- Use of products containing Senna may interact with cardiac glycosides (digitalis), antiarrhythmics, estrogens, indomethacin, and nifedipine.
- Consult your doctor or pharmacist if you are taking other medications.

Side Effects

- It may cause the urine to change color to red or yellowish-brown, which is not clinically significant. Senna-containing products may cause abdominal pain and spasms in sensitive individuals.
- The C-Lax syrup formulation contains a natural, pleasant-tasting spearmint essential oil, which has carminative and antispasmodic effects.

Storage Conditions

Store below 30 °C, away from light and moisture.
keep away from light and moisture.
Close the bottle tightly after use.
The maximum period of use of the product after opening the bottle cap is 4 weeks.
Keep out of reach of children.

C-Lax Syrup "Active Ingredients"

Each 5 mL of the product contains **250 mg of liquid extract of Senna alexandrina leaves**, equivalent to **50 mg per 1 mL**. The extract is standardized to provide **7.5 mg of hydroxyanthracene glycosides, expressed as sennoside B, per 5 mL**. Each bottle contains a total of **90 mg of hydroxyanthracene glycosides**.

C-Lux Syrup "Frequently Asked Questions"

The senna plant (Cassia angustifolia or Cassia acutifolia) has traditionally been used as a natural remedy to relieve constipation. When formulated as a syrup, senna can provide several benefits by stimulating bowel movements and helping to relieve what is commonly described as a “sluggish bowel.” Below, we explain how senna works and its potential benefits.

1Who is C-Lax Syrup suitable for?

C-Lax Syrup by Dineh can be used by people ranging from children 2 years of age to adults (Children’s Laxative).

2What are the benefits of C-Lax Syrup?

The liquid extract of senna used in Dineh C-Lax Syrup passes through the small intestine without being absorbed and interacts with bacteria in the large intestine. This leads to increased peristaltic movement of the colon, helping improve the passage of intestinal contents.

3Natural Laxative Action

Senna leaves contain natural compounds called sennosides. After ingestion, these compounds are converted by bacteria in the large intestine into active metabolites, such as rhein anthrone, which stimulate the intestinal tissue.

4Stimulation of Bowel Movement (Peristalsis)

This stimulation, when senna is used appropriately, promotes contraction of the muscles of the large intestine and accelerates the movement of stool through the bowel. This action can be particularly helpful when bowel movements are slow or the bowel is described as “sluggish.”

5Rapid Action and Convenient Dosing

The syrup formulation allows for accurate measurement and convenient dose adjustment. Many people prefer syrup to capsules or herbal teas because it is easier to take and may have a more acceptable taste, which can help ensure that the correct amount is taken.

6Antispasmodic Effect (Reduction of Abdominal Discomfort)

By stimulating bowel movements, senna leaf extract may help relieve bloating, abdominal cramps, and discomfort associated with constipation, contributing to greater abdominal comfort.

7A Natural Alternative to Synthetic Laxatives

For people who prefer to avoid synthetic laxatives, senna leaf syrup may be considered a natural option. Many people prefer herbal medicines because they perceive them as gentler and more compatible with the body's natural processes.

8A Suitable Diet for Relieving Constipation

Although senna leaf syrup can help relieve constipation on its own, it is generally better to adopt a broader approach that includes the following:
Adequate fluid intake: Drinking enough water can support the laxative effect and help prevent dehydration.
Diet: Eating a fiber-rich diet, including fruits, vegetables, and whole grains, can help maintain regular bowel function.
Lifestyle: Regular physical activity and daily exercise can help naturally stimulate digestion and bowel movements.

1. PDR for Herbal Medicines, Fourth Edition (2008), 743-7.
2. E/S/C/O/P Monographs, (2003), 456-58.
3. Remington’s Pharmaceutical Sciences, (1990), 785-6.
4. Martindale, The Complete Drug Reference, 40th Edition (2020), 1957-8.
5. Text book of Natural Medicine, Fifth Edition (2021), 1248-9.
6. Herbal Medicine, Fourth Edition (2013), 663-6.
7. The review of natural products, Eighth Edition, (2014), 1622-5.
8. Naturalmedicines.therapeutic.com/database (2024), NatMed pro-professional monograph-senna.

C-Lax syrup is licensed by the Iranian Food and Drug Administration (IFDA) with a valid IRC registration.
Iran Registration Code (IRC): 4760637738518378

DINEH Iran Industries Complex
Customer Support: 98-21-61018
dinehiran.com

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